Psilocybin Research | Science of Microdosing, Healing & Consciousness

3+ years of research

* 3,000+ SoulCybin members

* 30,000+ data points

Microdosing Can Heal & Transform You. Here’s The Evidence.

Since 2022, We've Been Running One Of The World’s Largest Studies On The Real-World Impact Of Microdosing. Click The Areas Of Research To Discover The Outcomes.

These outcomes reveal what to expect from your microdosing journey

Unlike controlled laboratory studies, our research is collected from the direct experiences of thousands of SoulCybin members throughout their everyday lives.

This offers a real-world insight into how a consistent microdosing practice can support you on your sacred journey back to wellbeing.

Insight 1

Meaningful improvements within your first 90 days

Many members report noticeable improvements after following a consistent microdosing practice over 90 days or less. Everyone’s journey is unique, but this timeframe emerges continuously across thousands of responses.

Insight 2

Benefits across every area of your life

Improvements are repeatedly shown across emotional wellbeing, focus, creativity, relationships, productivity, spiritual connection, and other areas of life. The sheer diversity of these outcomes is one of our most compelling discoveries, and it’s supported by research covering over 30,000 data points.

Insight 3

Consistency is key

People who maintain a regular microdosing practice generally report better and more lasting improvements than those who microdose inconsistently, or stop after a few days or weeks.

Discover what a consistent microdosing practice can do for you

90 days is the magic number . Across our research, this repeatedly emerges as the period in which many people begin experiencing significant improvements across multiple areas of life.

For those who would like the right supplies, structure, and guidance throughout that journey, we created The Journey Within :

A lovingly curated box containing the essential microdosing blends, tools, and wisdom needed to support a complete 90-day practice and help you experience the best possible outcomes from your journey.

Whether you’re seeking emotional or soul healing, personal transformation, greater clarity, or a goal that’s deeply personal to you, The Journey Within is SoulCybin’s recommended starting point for beginner and experienced microdosers alike.

And it’s not just our research, here’s what other studies have found about psilocybin & microdosing

A note on the research:

Most clinical studies to date have examined carefully supervised therapeutic doses of psilocybin rather than microdosing. Microdosing-specific research is still developing, but these broader studies offer important insight into the biological and psychological processes that may contribute to the experiences our members report.

Rapid reductions in depressive symptoms

Across randomized trials, psilocybin has produced meaningful reductions in depressive symptoms, with some improvements appearing rapidly and continuing for several weeks.

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What researchers studied

A 2025 meta-analysis combined nine randomized controlled trials involving 602 participants with depression. It examined how psilocybin performed against placebo or other control conditions across the available clinical evidence.

One of the larger included trials separately studied 104 adults with moderate-to-severe major depressive disorder. Participants received either one supported 25 mg psilocybin session or an active niacin placebo.

What they found

Across the nine trials, psilocybin produced a moderate reduction in depression compared with control conditions. The researchers also found that results varied considerably between studies and became smaller in larger, better-controlled trials.

In the 104-person clinical trial, the psilocybin group experienced significantly greater reductions in depressive symptoms and functional impairment, with benefits emerging quickly and remaining measurable throughout the six-week study.

Why it matters

Taken together, the findings provide substantial evidence that supported psilocybin experiences can create antidepressant changes that extend well beyond the immediate effects of the substance, while also showing why larger and more rigorously blinded studies remain important.

References :

Borgogna, N. C., et al. “Incremental efficacy systematic review and meta-analysis of psilocybin-for-depression RCTs.” Psychopharmacology, 2025.

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Raison, C. L., et al. “Single-dose psilocybin treatment for major depressive disorder: A randomized clinical trial.” JAMA, 2023.

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Whole-life benefits

Clinical research suggests that the potential benefits of psilocybin can extend across anxiety, depression, optimism, meaning, spiritual wellbeing, and quality of life.

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What researchers studied

Researchers conducted a randomized, double-blind crossover trial involving 51 people experiencing anxiety or depression alongside a life-threatening cancer diagnosis.

Each participant received both a very low, placebo-like dose and a higher therapeutic dose of psilocybin during separate supported sessions.

What they found

The higher dose produced substantial reductions in depression and anxiety, together with improvements in quality of life, optimism, meaning, and spiritual wellbeing. Many of these changes remained evident six months after the session.

Why it matters

The study demonstrates how meaningful psychological change may spread across several interconnected areas of life rather than remaining limited to the relief of one symptom.

References :

Griffiths, R. R., et al. “Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial.” Journal of Psychopharmacology, 2016.

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A more flexible and integrated brain

Brain-imaging research shows that psilocybin can temporarily disrupt rigid patterns of brain activity and allow normally separated networks to communicate in new ways.

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What researchers studied

One study analyzed brain scans from two clinical trials of psilocybin therapy for depression. Researchers examined whether changes in the organization of participants’ brain networks were connected to their antidepressant response.

A separate 2024 study used repeated precision brain scans to follow healthy adults before, during, and for three weeks after a supported 25 mg psilocybin session.

What they found

In the depression trials, improvement was associated with reduced separation between brain networks and greater global integration. Networks rich in serotonin 2A receptors became more interconnected and flexible following treatment.

The 2024 study found that psilocybin profoundly disrupted participants’ usual patterns of functional connectivity during the experience. Most changes were temporary, although reduced connectivity between the anterior hippocampus and default mode network remained detectable for several weeks.

Why it matters

These findings offer a plausible explanation for why psilocybin may help loosen entrenched patterns of thought, emotion, and self-perception: it temporarily reduces the brain’s usual boundaries and allows activity to reorganize in less rigid ways.

References :

Daws, R. E., et al. “Increased global integration in the brain after psilocybin therapy for depression.” Nature Medicine, 2022.

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Siegel, J. S., et al. “Psilocybin desynchronizes the human brain.” Nature, 2024.

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Lasting positive change from just one dose

New human research suggests that some psychological and brain-related changes can remain measurable for weeks after a single psilocybin experience.

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What researchers studied

A 2026 exploratory study followed 28 healthy adults who had never previously taken a psychedelic. Researchers used brain imaging, electrical brain recordings, and psychological assessments before and after a 25 mg psilocybin session.

Participants were assessed during the experience and again up to one month later.

What they found

One month after the session, participants showed increases in cognitive flexibility, psychological insight, and wellbeing.

Researchers also observed changes in measures related to prefrontal-subcortical brain structure, while greater acute brain-signal complexity predicted stronger improvements in later wellbeing. However, lasting changes in overall functional brain connectivity were largely absent.

Why it matters

The study offers early human evidence that psilocybin can be followed by psychological changes and measurable brain correlates that outlast the immediate experience. Because the study was small and exploratory, the results should be understood as promising rather than conclusive.

References :

Lyons, T., et al. “Human brain changes after first psilocybin use.” Nature Communications, 2026.

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Enhanced creativity that lasts

Psilocybin may encourage spontaneous insight during the experience and support the generation of new ideas after its immediate effects have passed.

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What researchers studied

A double-blind, placebo-controlled study examined several different forms of creativity during a psilocybin experience and again seven days later.

Researchers distinguished between spontaneous creative insights and deliberate, task-based creative performance.

What they found

During the experience, participants reported more spontaneous insights but performed less effectively on some deliberate creativity tasks.

Seven days later, participants who had received psilocybin generated a greater number of novel ideas than those who received placebo, although not every measure of creativity improved.

Why it matters

The findings show that psilocybin does not simply switch creativity “on.” Instead, it may influence different stages of the creative process in different ways—opening space for spontaneous insight before supporting the later development of novel ideas.

References :

Mason, N. L., et al. “Spontaneous and deliberate creative cognition during and after psilocybin exposure.” Translational Psychiatry, 2021.

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What microdosing research currently shows

Real-world studies repeatedly identify encouraging improvements among microdosers, while blinded clinical studies have not yet reproduced most of these benefits consistently.

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What researchers studied

One large observational study followed 953 psilocybin microdosers and 180 non-microdosing participants for approximately one month.

A separate double-blind, placebo-controlled study followed 34 people beginning a psilocybin mushroom microdosing practice.

More recently, a 2026 umbrella review evaluated existing reviews and meta-analyses drawing upon 14 studies and 1,614 participants.

What they found

The observational study found small-to-moderate improvements in mood, depression, anxiety, and stress among microdosers compared with non-microdosers.

The smaller placebo-controlled study found noticeable subjective effects but did not demonstrate reliable improvements in wellbeing, creativity, or cognitive performance.

The 2026 umbrella review found no consistent evidence that microdosing enhances cognition. Self-reported mood improvements also became substantially weaker under blinded, placebo-controlled conditions, suggesting that expectation may contribute to some reported benefits.

Why it matters

These results reveal an important gap in the evidence. Large real-world studies repeatedly uncover encouraging patterns, while short controlled trials have not yet established how much of the benefit comes directly from the microdose itself.

SoulCybin’s research contributes to this developing field by showing what thousands of people report across longer, everyday microdosing journeys. Controlled trials and real-world research answer different questions: one helps test cause and effect, while the other reveals patterns, experiences, and long-term outcomes that may be difficult to capture in a laboratory.

References :

Rootman, J. M., et al. “Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls.” Scientific Reports, 2022.

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Cavanna, F., et al. “Microdosing with psilocybin mushrooms: A double-blind placebo-controlled study.” Translational Psychiatry, 2022.

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Özaydın, Y., and B. C. Özaydın. “Classical psychedelic microdosing, mood, and cognitive function: An umbrella review with narrative synthesis.” Journal of Psychopharmacology, 2026.

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Explore our curated selection of scientific literature on psilocybin and its impact on human wellness.

Coming Soon

Our commitment to ongoing discovery

Since beginning our mission in 2022, our community has expanded to over 55,000 people across all 50 U.S. states. This offers us a unique opportunity to keep contributing to the growing body of research on psilocybin and microdosing.

We believe humanity needs this sacred medicine now more than ever!

And so we pledge to continue learning and sharing our findings, in the hope that it benefits you in gaining the fullest benefits of this profound natural gift.

Begin your microdosing journey with SoulCybin

In addition to The Journey Within box, which is our recommended starting point, we also invite you to explore our full range of microdosing blends and offerings.

From inner peace and cognitive performance, to energy, inner guidance, and spiritual exploration, you’ll find a SoulCybin blend for every intention.

3+ years of research

* 3,000+ SoulCybin members

* 30,000+ data points

Microdosing Can Heal & Transform You. Here’s The Evidence.

Since 2022, We've Been Running One Of The World’s Largest Studies On The Real-World Impact Of Microdosing. Click The Areas Of Research To Discover The Outcomes.

Select your area of interest to reveal the research

Conditions I want to treat

Outcomes I want to achieve

Depression: significant improvements for majority in 90 days

The science: Microdosing can interrupt rigid negative thinking and increase psychological flexibility, helping depressive patterns loosen and positive engagement return.

“I started microdosing to replace my antidepressants which were creating health issues. Since beginning my (microdosing) journey… I had fewer withdrawal symptoms coming off my meds and an increase in my ability to safely feel my emotions.”

Leeann, January 19th 2025

Anxiety: significant improvements for majority in 90 days

The science: Microdosing can reduce threat-focused emotional reactivity and create more flexible responses to stress, supporting a calmer emotional baseline.

“The use of this sacred medicine has changed my relationships. I have no anxiety, I have patience, my mind is clearer.. I am not afraid to live. Thank you.”

V, April 4th 2024

Panic attacks: significant improvements for majority in 60 days

The science: By reducing underlying anxiety and softening automatic threat responses, microdosing can help weaken the cycle of fear that fuels panic.

“The last few years have been unbearable, but since I’ve started with (microdosing) my ADHD symptoms have decreased significantly, anxiety and panic attacks have basically disappeared, and I’ve been able to live life.”

Taylor, October 24th 2021

PTSD: significant improvements for majority in 60 days

The science: Microdosing can create greater emotional flexibility and support fear-extinction learning, helping traumatic fear responses become easier to revisit and update.

“Microdosing provided the much-needed relief I needed in dealing with PTSD from being a front-line caregiver in an ICU during the pandemic combined with my peri-menopausal mood swings. Relief was immediate! I’m sleeping and coping much better.”

MO, October 22nd 2021

ADD/ADHD: moderate-to-significant improvements in 30 days

The science: Microdosing can support emotional regulation and day-to-day engagement in people with ADHD.

“I have used Soulcybin (offerings) in the treatment of some of my patients. In particular a 17-year-old ADHD patient has scored 20 points higher on average on school exams, using (a microdosing offering) once a week for 5 weeks.”

Dr Mike, New York, February 26th 2023

OCD: significant improvements for majority in 90 days

The science: Microdosing can loosen rigid thought loops and reduce compulsive symptoms by increasing flexibility in how repetitive thoughts are experienced and processed.

"I love how (microdosing) affects me and opens my mind to becoming more aware and freer of obsessive thoughts, which frees me more from suffering.”

Jerrold Fields, April 11, 2024

Phobias: moderate-to-significant improvements in 30 days

The science: Microdosing supports fear-extinction learning in preclinical research, helping the brain replace an entrenched fear response with a new sense of safety.

“I’ve been in talk therapy for many years, but not until I discovered the benefits of microdosing have I been able to begin to fully understand and release the fear I’ve been struggling with (often subconsciously) since I was a child.”

Kate, November 5th, 2023

Loneliness: significant improvements for majority in 90 days

The science: Microdosing can strengthen feelings of connection to oneself and others, helping soften the isolation and disconnection at the heart of loneliness.

“At 68 I was widowed; alone… I felt my mind had no more room left. I started (microdosing) about 4.5 months ago. I’ve finally been able to work through; let go of all the “baggage”, literally the drama melted away like glittery tears.”

Kaleigh, July 13th 2025

Creativity: significant improvements for majority in 30 days

The science: Microdosing can loosen habitual associations and increase cognitive flexibility, allowing fresh ideas and unexpected connections to emerge.

Seth Bartlet, September 30th 2021

Productivity: significant improvements for majority in 30 days

The science: Microdosing can support motivation and task engagement, helping people build momentum and follow through more consistently.

Karen, March 15th 2024

Focus: significant improvements for majority in 30 days

The science: Microdosing can help people feel less mentally scattered and more engaged with a chosen task.

“The way this medicine helps me is that it keeps me grounded. It pulls me back into my own body and I am more able to focus on the task at hand rather than all the worries I’m usually consumed with. It quiets the storm inside my mind and helps me feel motivated to tackle daily tasks.”

Ashley, August 4th 2023

Memory: significant improvements for majority in 30 days

The science: By supporting greater attention and mental engagement, microdosing can help everyday information (such as names, facts, and important details) feel easier to retain and recall.

“I’m a 64-year-old guy who’s constantly tweaking my approach to mental and physical well-being. (After microdosing) I am feeling the change. My mental clarity, ability to recall facts, be more “present”, etc. have definitely improved.

Bill C., June 20th 2022

Connectivity: significant improvements for majority in 30 days

The science: Microdosing can strengthen feelings of connection to oneself, other people, and the wider world by temporarily softening rigid self-boundaries.

GM, August 13th 2023

Happiness: significant improvements for majority in 30 days

The science: Microdosing can reduce negative emotional bias and increase positive mood, making feelings of joy and optimism more accessible.

Paul Mayer, July 16th 2023

Presence: significant improvements for majority in 30 days

The science: Microdosing can quiet habitual self-focused processing and heighten awareness of immediate experience, supporting a stronger sense of presence.

“Since I’ve been microdosing, my mind has been freed. I’m able to live in the moment and quit fretting about past and future events. Makes life much more enjoyable.”

Melanie, September 16th 2023

Quality of life: significant improvements for majority in 90 days

The science: By improving mood, meaning, connection, and emotional flexibility together, microdosing can create positive changes that extend across overall quality of life.

“Microdosing has literally saved my life after decades of trying everything else. The fog has liftedand I don’t want to die each morning when I wake. The clarity and calm that I have is amazing, even when faced with former things that were triggers.”

Stacey, January 27th 2024

These outcomes reveal what to expect from your microdosing journey

Unlike controlled laboratory studies, our research is collected from the direct experiences of thousands of SoulCybin members throughout their everyday lives.

This offers a real-world insight into how a consistent microdosing practice can support you on your sacred journey back to wellbeing.

Insight 1

Meaningful improvements within your first 90 days

Many members report noticeable improvements after following a consistent microdosing practice over 90 days or less. Everyone’s journey is unique, but this timeframe emerges continuously across thousands of responses.

Insight 2

Benefits across every area of your life

Insight 3

Consistency is key

People who maintain a regular microdosing practice generally report better and more lasting improvements than those who microdose inconsistently, or stop after a few days or weeks.

Discover what a consistent microdosing practice can do for you