Perturbing a system and observing the consequences is a classic scientific strategy for understanding a phenomenon. Psychedelic drugs perturb consciousness in a marked and novel way and thus are powerful tools for studying its mechanisms. In the present analysis, we measured changes in resting-state functional connectivity (RSFC) between a standard template of different independent components analysis (ICA)-derived resting state networks (RSNs) under the influence of two different psychoactive drugs, the stimulant/psychedelic hybrid, MDMA, and the classic psychedelic, psilocybin. Both were given in placebo-controlled designs and produced marked subjective effects, although reports of more profound changes in consciousness were given after psilocybin. Between-network RSFC was generally increased under psilocybin, implying that networks become less differentiated from each other in the psychedelic state. Decreased RSFC between visual and sensorimotor RSNs was also observed. MDMA had a notably less marked effect on between-network RSFC, implying that the extensive changes observed under psilocybin may be exclusive to classic psychedelic drugs and related to their especially profound effects on consciousness. The novel analytical approach applied here may be applied to other altered states of consciousness to improve our characterization of different conscious states and ultimately advance our understanding of the brain mechanisms underlying them.
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The SoulCybin team exceeded my expectations with the way they handled my order. I explained in the order notes that my need for product to enable me to continue my microdosing schedule was very important, that I was nearly out, and they caringly responded by sending my order out within that week. Incredible turn around time and it clearly demonstrates their outstanding customer service . . . they read the requests from their customers. So rare and valuable!
Briefly, why I microdose: while working for more than 10 years for one of the big tech companies in the Pacific NW, I experienced major burnout. The stresses of the job, the frequent re-organization of teams and constant worry about being laid off added up thru the years and before I knew it I had slipped into depression. Exercise, eating right, and even meditation was not helping me. I tried psychologists and psychiatrists who put me on big pharma anti-depressant drugs, but none of that worked. I kept getting worse and was at risk of losing my job, marriage and family, who didn’t understand why I was: unhappy, quick to get angry, and disconnected from them nearly all the time.
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